24 Nov 2025
Innovative nanotechnology is reshaping how we tackle drug-resistant infections
Researchers at the Institute of Biomedical Engineering have developed DNAse-loaded gold nanocones that offer a powerful new approach to biofilm disruption and enhanced antimicrobial therapy. Biofilms are a major barrier to effective drug delivery, especially in persistent infections.
Our research has shown that DNAse-loaded gold nanocones can:
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Mechanically disrupt biofilms through acoustic cavitation
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Release DNAse to prevent biofilm formation and promote bacterial clearance
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Work synergistically with antibiotics such as ciprofloxacin to reduce the required dosage and improve efficacy.
Using ultrasound at 2MPa, the combination of DNAse-loaded nanocones and ciprofloxacin achieved nearly 100% biofilm removal and significantly reduced bacterial viability. This approach also lowered the minimum inhibitory concentration needed for treatment.
This research, led by Dr Qiang Wu and supervised by Prof Eleanor Stride, demonstrates the potential of nanomaterials to enhance antibiotic performance and overcome resistance mechanisms.
This research is funded by the Engineering and Physical Science Research Council (EPSRC) Programme Grant Scheme under the reference number EP/V026623/1.
