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Beyond Antibiotics

Beyond Antibiotics

A Programme Grant funded by the Engineering and Physical Sciences Research Council (EPSRC)

The UN Interagency Coordinating Group on Antimicrobial Resistance estimates that drug-resistant infections could cause 10 million deaths each year by 2050 and an annual economic cost of £69 trillion [1]. There have been significant efforts by national and international agencies to raise awareness of AMR and reduce antibiotic use, but there is still an urgent need to intensify these efforts and, crucially, to develop better diagnostics and alternative therapeutic options.  

The causes of AMR are multiple and complex, but central to the current crisis has been the combination of: (a) overuse and misuse of antibiotics in medical, veterinary and agricultural settings, in part driven by the lack of rapid point-of-care diagnostics, (b) dissemination of antibiotics and antibiotic-resistant bacteria in the environment through sewage, manure and pharmaceutical manufacturing waste, and (c) a stalled pipeline of novel antibiotics to replace or supplement the loss of existing drugs. Immediately following the 2019 report, The UN issued a call-for-innovation paper [2]. Yet despite this and similar initiatives to stimulate research, development of new antibiotics is widely viewed as commercially unviable and industrial development of alternatives as excessively risky [3]. There have already been essential advances in understanding the biological mechanisms of AMR and its epidemiology from the Biological, Medical and Social Sciences. The aim of this programme is to match this with an equal contribution from the Engineering and Physical Sciences to overcome the technical barriers to translating that understanding into viable, disruptive solutions.  

The primary focus of our EPSRC Programme Grant Scheme funded research (EP/V026623/1) is the development of new technology to enable: better characterisation of bacterial infections, rapid point-of-care diagnostics, high-throughput testing of new therapies, alternatives to antibiotics and infection prevention strategies. As recognised by the UN call-for-innovation [2], the creation of this technology represents a critical unmet need. To have a significant impact, it is essential that this development is also integrated with the wider global efforts on tackling AMR. As detailed below, we will achieve this through extensive engagement with AMR research networks and our clinical, industrial and policy partners. The aim within the 5 year programme is to provide a set of commercially viable and effective technologies to address the need for transformative innovation. 

This research is funded by the Engineering and Physical Science Research Council (EPSRC) Programme Grant Scheme under the reference number EP/V026623/1. 


[2] innovation_research_boost_RD_and_access_110618.pdf  

[3] Singer et al. (2019) The Lancet - in press (DOI:10.1016/S1473-3099(19)30552-3) 

Principal Investigator

Professor Eleanor Stride

Collaborating Institutions

  • The University of Oxford (lead)
  • University College London
  • Ulster University
  • University of Cambridge


UKRI - Engineering and Physical Sciences Research Council (EPSRC). Programme Grant Scheme EP/V026623/1.


  • Karl Storz GmbH & Co KG 
  • Smith + Nephew plc 
  • Boston Scientific Corporation 
  • GSK 
  • Public Health England 
  • Norbrook Laboratories Ltd 
  • National Biofilms Innovation Centre 
  • Phillips International B.V. 
  • Oxford NanoImaging  


NEW: Teacher and Student Resource includes Antimicrobial Resistance Component

Royal Academy of Engineering

"Working in AMR is incredibly exciting. The multi-disciplinary aspect of the research allows me to meet and work with many interesting people, with a vast range of backgrounds. The work is very rewarding as we strive to improve lives globally for years to come." @aaroncrowther2

"I never thought I would be using ultrasound and microbubbles. When microbubbles are stimulated with ultrasound they have the ability to disrupt bacterial biofilms, making them an interesting and effective delivery vehicle for antibiofilm and antibiotic agents." @aaroncrowther2

@aaroncrowther2 is a pharmaceutical scientist with a research interest in drug delivery. His interest in AMR started during his MRes project focussed on developing a deeper understanding of the mechanisms responsible for multi-drug resistant gonorrhoea infections.

RT @saveantibiotics: "Most people do not realize the walls are closing in around them," @RickABright warns of the growing threat of #antibi

This research is funded by the Engineering and Physical Science Research Council (EPSRC) Programme Grant Scheme under the reference number EP/V026623/1.